Datasets related to microbiota-dependent regulation of mouse colonic epithelial cells

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Nirello, Vinicius Dias; Vinolo, Marco Aurélio Ramirez; Varga-Weisz, Patrick Daniel, 2026, "Datasets related to microbiota-dependent regulation of mouse colonic epithelial cells", https://doi.org/10.25824/redu/3JAARS, Repositório de Dados de Pesquisa da Unicamp, V1
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Description
Este conjunto de dados compreende dados de transcriptômica de célula única de células epiteliais colônicas de camundongos, dados de sequenciamento do gene 16S rRNA para caracterização da microbiota intestinal e quantificações histológicas de contagem celular. O propósito do dataset é investigar a regulação dependente da microbiota sobre a identidade, composição e respostas funcionais do epitélio intestinal em diferentes condições experimentais, incluindo camundongos tratados com antibióticos, specific pathogen free e germ-free. O conjunto inclui matrizes de contagem gene × célula processadas, tabelas de abundância taxonômica da microbiota, quantificações histológicas e metadados experimentais associados que sustentam as análises apresentadas na tese e na publicação correspondente. Os dados de sequenciamento gerados neste estudo encontram-se depositados no NCBI, BioProject PRJNA1136851 (16S amplicon sequencing) e BioProject PRJNA1136828 (single-cell gene expression profiling). Os dados suplementares associados estão disponíveis no DOI: https://doi.org/10.1080/19490976.2025.2573045
Subject Medicine, Health and Life Sciences
Keyword Gene expression, Single-cell gene expression analysis, Host microbial interactions, Intestinal mucosa
Related Publication Dias Nirello, V., Araújo, N., Carvalho de Assis, H., Moreno-Gonzalez, M., Ruiz, P., Castro, P. R., … Varga-Weisz, P. (2025). Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate–GP R109A signalling. Gut Microbes, 17(1). https://doi.org/10.1080/19490976.2025.2573045 doi: 10.1080/19490976.2025.2573045
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