Dados de pesquisa: gliconeogênese renal em camundogos obesos e exercício

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Canciglieri, Raphael dos Santos; Moura, Leandro Pereira de, 2025, "Dados de pesquisa: gliconeogênese renal em camundogos obesos e exercício", https://doi.org/10.25824/redu/5GVRU4, Repositório de Dados de Pesquisa da Unicamp, V1
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Description
O conjunto de dados foi gerado com o propósito de investigar os efeitos da obesidade induzida por dieta hiperlipídica e da intervenção com exercício físico aeróbico sobre os mecanismos moleculares e bioenergéticos associados à gliconeogênese renal e à função mitocondrial. O objetivo principal foi compreender de que forma a resistência à insulina afeta as vias metabólicas renais relacionadas ao controle glicêmico e se o treinamento aeróbico é capaz de modular esses efeitos em nível transcricional e proteico. Os dados fundamentam a tese de doutorado de Raphael dos Santos Canciglieri, desenvolvida no Programa de Pós-Graduação em Nutrição, Esporte e Metabolismo (CNEM) da Universidade Estadual de Campinas (UNICAMP), e contribuem para o entendimento dos mecanismos renais envolvidos na homeostase glicêmica em condições de obesidade e resistência à insulina. O conjunto inclui dados quantitativos e qualitativos obtidos de experimentos conduzidos com camundongos machos Swiss, distribuídos em três grupos experimentais: Controle (CT), Obeso Sedentário (OBS) e Obeso Aeróbico (OBA). Os dados abrangem: Medidas de peso corporal e ganho ponderal semanal; Testes de tolerância à insulina; Expressão gênica relativa (qPCR) de transportadores de solutos, inflamação, estresse de reticulo e genes relacionados à biogênese mitocondrial (Slc5a2, Slc5a3, Slc4a4, Slc13a2, Ppargc1a, Tfam, Cyb1); Expressão proteica obtida por Western blot para IRS-1 total, phospho-IRS-1 (Ser612), OXPHOS, G6Pase e PEPCK, com quantificação densitométrica realizada nos softwares ImageJ (Fiji, NIH, EUA) e UNIscanit 6.1 (Silk Scientific, EUA); Dados de respirometria mitocondrial de alta resolução (Oroboros O2k®) avaliando os estados acoplado (OXPHOS) e desacoplado (ETS) dos complexos I e II. Os arquivos estão organizados em planilhas .xlsx e .csv, contendo dados numéricos originais e tratados. O escopo do conjunto de dados abrange experimentos realizados durante o periodo de doutorado no Laboratório Ecebil. Os dados representam medições originais e reproduzíveis que sustentam a análise dos efeitos da obesidade e do exercício físico sobre a gliconeogênese renal, a sinalização da insulina e a biogênese mitocondrial.O conjunto serve como base para futuras pesquisas em fisiologia renal, metabolismo energético e doenças metabólicas (2025-11-07)
Subject Medicine, Health and Life Sciences
Keyword Obesidade, Gliconeogênese renal, Biogênese mitocondrial, Exercício físico, Resistência à insulina, Respirometria mitocondrial
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REDU - Dados Tese.xlsx
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Published Dec 9, 2025
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