Respostas de neutrófilos humanos à disbiose intestinal induzida por antibióticos: um conjunto de dados longitudinal multiômico com caracterização imunológica e clínica

Version 1.0

Pereira, Bruna Toledo Nunes; Vinolo, Marco Aurélio Ramirez, 2026, "Respostas de neutrófilos humanos à disbiose intestinal induzida por antibióticos: um conjunto de dados longitudinal multiômico com caracterização imunológica e clínica", https://doi.org/10.25824/redu/6XFA33, Repositório de Dados de Pesquisa da Unicamp , V1

Learn about Data Citation Standards.

Contact Owner

Dataset Metrics

0 Downloads

Description	Este conjunto de dados reúne dados longitudinais multiômicos e de perfis imunológicos/clínicos, gerados como parte de um projeto de doutorado na Unicamp, que investiga como a disbiose intestinal induzida por antibióticos modula neutrófilos humanos. Inclui amostras pareadas pré- e pós-antibiótico de adultos saudáveis submetidos a um regime de amplo espectro por três dias (coletas realizadas em 2021-2022), possibilitando análises pareadas de medidas do hospedeiro e do microbioma. As medidas incluem transcriptômica de neutrófilos (RNA-seq), epigenômica de neutrófilos (ATAC-seq) e análise do perfil da microbiota fecal (sequenciamento de amplicons do 16S rRNA), além de quantificação de citocinas, citometria de fluxo, RT-qPCR, entre outros. Os dados não podem ser disponibilizados por questões de proteção intelectual. Para mais informações, favor contatar os responsáveis pelo depósito. This dataset comprises longitudinal multi-omics and immune/clinical profiling data generated as part of a doctoral project at UNICAMP investigating how antibiotic-induced gut dysbiosis modulates human neutrophils. It includes matched pre- and post-antibiotic samples from healthy adults following a three-day broad-spectrum regimen (collected in 2021-2022), enabling paired analyses of host and microbiome readouts. Readouts include neutrophil transcriptomics (RNA-seq), neutrophil epigenomics (ATAC-seq), and fecal microbiome profiling (16S rRNA amplicon sequencing), as well as cytokine quantification, flow cytometry, RT-qPCR, and related measures. The data cannot be made available due to intellectual property protection. For further information, please contact the repository administrators.
Subject	Medicine, Health and Life Sciences
Keyword	Neutrophils, Host–microbiome interactions, Antibiotic-induced dysbiosis, Gut microbes, Innate immunity
Notes	[PT] Os dados brutos de sequenciamento foram depositados em repositórios públicos da seguinte forma: os dados de bulk RNA-seq e bulk ATAC-seq estão disponíveis no NCBI BioProject PRJNA1402444, e os dados de sequenciamento de amplicons de 16S rRNA estão disponíveis no NCBI BioProject PRJNA1402306. Todos os scripts gerados durante este estudo estão disponíveis no GitHub: https://github.com/Laboratorio-de-Imunoinflamacao-UNICAMP/human-antibiotic-dysbiosis-neutrophils * Todos os dados associados aos participantes foram devidamente anonimizados para garantir a confidencialidade e a proteção das informações pessoais. [EN] * Raw sequencing data have been deposited in public repositories as follows: bulk RNA-seq and bulk ATAC-seq data are available in the NCBI BioProject PRJNA1402444, and 16S rRNA amplicon sequencing data are available in the NCBI BioProject PRJNA1402306. * All scripts generated during this study are available on GitHub: https://github.com/Laboratorio-de-Imunoinflamacao-UNICAMP/human-antibiotic-dysbiosis-neutrophils * All participant-related data were anonymized to ensure confidentiality and protection of personal information.
License/Data Use Agreement	CC BY-NC 4.0


There are no files in this dataset.

Citation Metadata

Persistent Identifier	doi:10.25824/redu/6XFA33
Publication Date	2026-03-13
Title	Respostas de neutrófilos humanos à disbiose intestinal induzida por antibióticos: um conjunto de dados longitudinal multiômico com caracterização imunológica e clínica
Alternative Title	Human neutrophil responses to antibiotic-induced gut dysbiosis: longitudinal multi-omics and immune/clinical profiling dataset
Alternative URL	https://github.com/Laboratorio-de-Imunoinflamacao-UNICAMP/human-antibiotic-dysbiosis-neutrophils
Author	Pereira, Bruna Toledo Nunes (Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.) - ORCID: https://orcid.org/0000-0003-1245-685X Vinolo, Marco Aurélio Ramirez (Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.) - ORCID: https://orcid.org/0000-0003-1335-760X
Point of Contact	Use email button above to contact. Vinolo, Marco Aurélio Ramirez (Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.)
Description	Este conjunto de dados reúne dados longitudinais multiômicos e de perfis imunológicos/clínicos, gerados como parte de um projeto de doutorado na Unicamp, que investiga como a disbiose intestinal induzida por antibióticos modula neutrófilos humanos. Inclui amostras pareadas pré- e pós-antibiótico de adultos saudáveis submetidos a um regime de amplo espectro por três dias (coletas realizadas em 2021-2022), possibilitando análises pareadas de medidas do hospedeiro e do microbioma. As medidas incluem transcriptômica de neutrófilos (RNA-seq), epigenômica de neutrófilos (ATAC-seq) e análise do perfil da microbiota fecal (sequenciamento de amplicons do 16S rRNA), além de quantificação de citocinas, citometria de fluxo, RT-qPCR, entre outros. Os dados não podem ser disponibilizados por questões de proteção intelectual. Para mais informações, favor contatar os responsáveis pelo depósito. This dataset comprises longitudinal multi-omics and immune/clinical profiling data generated as part of a doctoral project at UNICAMP investigating how antibiotic-induced gut dysbiosis modulates human neutrophils. It includes matched pre- and post-antibiotic samples from healthy adults following a three-day broad-spectrum regimen (collected in 2021-2022), enabling paired analyses of host and microbiome readouts. Readouts include neutrophil transcriptomics (RNA-seq), neutrophil epigenomics (ATAC-seq), and fecal microbiome profiling (16S rRNA amplicon sequencing), as well as cytokine quantification, flow cytometry, RT-qPCR, and related measures. The data cannot be made available due to intellectual property protection. For further information, please contact the repository administrators.
Subject	Medicine, Health and Life Sciences
Keyword	Neutrophils (DLC (LCSH)) Host–microbiome interactions Antibiotic-induced dysbiosis Gut microbes Innate immunity
Notes	[PT] Os dados brutos de sequenciamento foram depositados em repositórios públicos da seguinte forma: os dados de bulk RNA-seq e bulk ATAC-seq estão disponíveis no NCBI BioProject PRJNA1402444, e os dados de sequenciamento de amplicons de 16S rRNA estão disponíveis no NCBI BioProject PRJNA1402306. Todos os scripts gerados durante este estudo estão disponíveis no GitHub: https://github.com/Laboratorio-de-Imunoinflamacao-UNICAMP/human-antibiotic-dysbiosis-neutrophils * Todos os dados associados aos participantes foram devidamente anonimizados para garantir a confidencialidade e a proteção das informações pessoais. [EN] * Raw sequencing data have been deposited in public repositories as follows: bulk RNA-seq and bulk ATAC-seq data are available in the NCBI BioProject PRJNA1402444, and 16S rRNA amplicon sequencing data are available in the NCBI BioProject PRJNA1402306. * All scripts generated during this study are available on GitHub: https://github.com/Laboratorio-de-Imunoinflamacao-UNICAMP/human-antibiotic-dysbiosis-neutrophils * All participant-related data were anonymized to ensure confidentiality and protection of personal information.
Funding Information	Fundação de Amparo à Pesquisa do Estado de São Paulo: FAPESP: 2020/00465-7 Fundação de Amparo à Pesquisa do Estado de São Paulo: FAPESP: 2018/15313-8
Depositor	Pereira, Bruna Toledo Nunes
Deposit Date	2025-08-29
Declarações obrigatórias sobre ética e privacidade	o projeto que gerou os dados foi aprovado pelo Comite de Ética em Pesquisa da Unicamp ou não envolve questões que requeiram tal aprovação; os dados que serão depositados estão de acordo com a LGPD (Lei Geral de Proteção de Dados)

Dataset Terms

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

CC BY-NC 4.0

Dataset Version	Summary	Contributors	Published on
No records found.

Edit File

This file has already been deleted (or replaced) in the current version. It may not be edited.

Restrict Access

Restricting limits access to published files. People who want to use the restricted files can request access by default. If you disable request access, you must add information about access to the Terms of Access field.

Learn about restricting files and dataset access in the User Guide.

Request Access

Enable access request

You must enable request access or add terms of access to restrict file access.

Terms of Access for Restricted Files

Save Changes

Edit Embargo

The selected file or files have already been published. Contact an administrator to change the embargo date or reason of the file or files.

Delete Files

The file will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Select File(s)

Please select one or more files.

Share Dataset

Share this dataset on your favorite social media networks.

Dataset Citations

Citations for this dataset are retrieved from Crossref via DataCite using Make Data Count standards. For more information about dataset metrics, please refer to the User Guide.

Sorry, no citations were found.

Restricted Files Selected

The selected file(s) may not be downloaded because you have not been granted access.

Download Options

The files selected are too large to download as a ZIP.

You can select individual files that are below the 953.7 MB download limit from the files table, or use the Data Access API for programmatic access to the files.

Select File(s)

Please select a file or files to be downloaded.

Restricted Files Selected

The restricted file(s) selected may not be downloaded because you have not been granted access.

Click Continue to download the files you have access to download.

Delete Dataset

Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.

Delete Draft Version

Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.

Unpublished Dataset Private URL

Private URL can only be used with unpublished versions of datasets.

Unpublished Dataset Private URL

Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your unpublished dataset.

Delete Files

The file(s) will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Compute

This dataset contains restricted files you may not compute on because you have not been granted access.

Deaccession Dataset

Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.

Deaccession Dataset

Are you sure you want to deaccession this dataset? It will no longer be viewable by the public.

Version Differences Details

Please select two versions to view the differences.

Version Differences Details

Version:
Last Updated:

Select File(s)

Please select a file or files for access request.

Select File(s)

Embargoed files cannot be accessed. Please select an unembargoed file or files for your access request.

Edit Tags

Select existing file tags or create new tags to describe your files. Each file can have more than one tag.

Request Access

You need to Log In to request access.

Dataset Terms

This dataset is made available under the following terms. Please confirm and/or complete the information needed below in order to continue.

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

CC BY-NC 4.0

Preview Guestbook

Upon downloading files the guestbook asks for the following information.

Guestbook Name

Collected Data

Account Information

Package File Download

Use the Download URL in a Wget command or a download manager to download this package file. Download via web browser is not recommended. User Guide - Downloading a Dataverse Package via URL

Download URL

https://redu.unicamp.br/api/access/datafile/

Request Access

Please confirm and/or complete the information needed below in order to request access to files in this dataset.

Compute Batch

Clear Batch

Dataset	Persistent Identifier	Change Compute Batch

Compute Batch

Submit for Review

You will not be able to make changes to this dataset while it is in review.

Publish Dataset

Are you sure you want to republish this dataset?

Select if this is a minor or major version update.

Minor Release (1.1)

Major Release (2.0)

Publish Dataset

This dataset cannot be published until Biomédicas is published by its administrator.

Publish Dataset

This dataset cannot be published until Biomédicas and Repositório de Dados de Pesquisa da Unicamp are published.

Return to Author

Return this dataset to contributor for modification.