Dados relativos à pesquisa de epigenômica e transcriptômica de célula única de malformações corticais e do cérebro pediátrico

Version 1.0
Galvão, Isabella Cotta; Lemoine, Manuela; Messias, Lauana Andrade; Kandratavicius, Ludmyla; Araujo, Patricia Aline Oliveira Ribeiro de Aguiar; Geraldis, Jaqueline Cruz; Alvim, Marina Koutsodontis Machado; Yasuda, Clarissa Lin; Ghizoni, Enrico; Tedeschi, Helder; Cendes, Fernando; Rogerio, Fabio; Lopes-Cendes, Íscia Teresinha; Veiga, Diogo Fernando, 2026, "Dados relativos à pesquisa de epigenômica e transcriptômica de célula única de malformações corticais e do cérebro pediátrico", https://doi.org/10.25824/redu/BXZSFM, Repositório de Dados de Pesquisa da Unicamp , V1
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Description
Três conjuntos de dados referentes ao sequenciamento multiômico de célula única (snATAC-seq + snRNA-seq) de: (i) lesões de displasia cortical focal (n = 3 FCD IIa; n = 6 FCD IIb) e controles internos da área adjacente à lesão (n = 2); dados disponíveis em https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268807 e https://explore.data.humancellatlas.org/projects/9762d70c-9b27-4f57-8cbc-377b9b92ea9b; o objeto processado está disponível em https://cellxgene.cziscience.com/collections/9e4e8f1d-d905-4d4f-b343-84889d0f9ffe (ii) substância branca (n = 2) e substância cinzenta (n = 2) de lesões MOGHE; dados disponíveis em https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284073; também foi feito sequenciamento de exoma completo desses pacientes, disponível em https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1275012/ (iii) amígdala (n = 3), córtex (n = 6) e hipocampo (n = 4) de tecido sem alterações histopatológicas de seis pacientes com idades entre 6 e 15 anos; dados disponíveis em https://explore.data.humancellatlas.org/projects/984ce0a2-682d-47a3-b80e-1354dfe51ca3; o objeto processado está disponível em https://cellxgene.cziscience.com/collections/4624894f-6cf7-45d2-91ff-51fff9da9f13; também foi feito sequenciamento de genoma completo desses pacientes, disponível em https://dataview.ncbi.nlm.nih.gov/object/PRJNA1261881?reviewer=436abbi8h9mllsm1u462c3dl0o (link para revisores) (2026-04-17)
Subject Medicine, Health and Life Sciences
Keyword Sequenciamento de célula única, Epigenômica, Transcriptômica, Neurodesenvolvimento, Displasia cortical focal, MOGHE
Related Publication GALVÃO, Isabella C. et al. Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia. iscience, v. 27, n. 12, 2024. doi: https://doi.org/10.1016/j.isci.2024.111337
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