Biosynthesis of pipecolic acid-derived cyclodepsipeptides produced by the fungus Penicillium brasilianum

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Maximo, Marina Ferreira; Akiyama, Daniel Yuri; Micklefield, Jason; Fill, Taicia Pacheco, 2026, "Biosynthesis of pipecolic acid-derived cyclodepsipeptides produced by the fungus Penicillium brasilianum", https://doi.org/10.25824/redu/CCT2RJ, Repositório de Dados de Pesquisa da Unicamp, V1
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Description
This study explores the biosynthesis of pipecolic acid-containing cyclodepsipeptides produced by the fungus Penicillium brasilianum LaBioMMi-136, an endophytic fungus from Melia azedarach. Through genome mining, gene knockout, and in vitro enzymatic assays, we identified a biosynthetic gene cluster responsible for their production and uncovered pipecolic acid's biosynthesis in the fungus. This dataset integrates LC-HRMS and NMR data. Access to the data is restricted for publication reasons. For further information, please contact the responsible authors. (2025-11-03)
Subject Chemistry
Keyword Biossíntese, Natural products, Genome mining, Heterologous expression
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