Cálculo de porcentagem de extrato em cosméticos com atividade de inibição de tirosinase

Version 1.1
Lindo, Santa Maria Del Rosário Orrillo; Ribeiro, Marcelo Perecin de Arruda; Bicas, Juliano Lemos; Leonardi, Gislaine Ricci, 2025, "Cálculo de porcentagem de extrato em cosméticos com atividade de inibição de tirosinase", https://doi.org/10.25824/redu/GRCRFE, Repositório de Dados de Pesquisa da Unicamp, V1
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Description
Dados referentes ao estudo da cinética enzimática da enzima tirosinase. Os coeficientes foram obtidos através de modelagem computacional, a qual se baseia nas equações descritas pela literatura (Michalis-Menten). Utilizando a modelagem computacional, calculou-se o coeficiente de inibição enzimático (Ki) de 13 extratos botânicos, feitos a partir de diferentes líquidos extratores e o ativo padrão 3-O-Ethyl Ascorbic Acid. Após a comparação dos coeficientes de inibição obtidos e seleção do extrato com maior potencial inibitório, prosseguiu-se para mensurar a porcentagem de extrato botânico em uma formulação cosmética, a fim de teoricamente inibir em 99% a atividade enzimática da tirosinase, utilizando dados derivados de modelagem computacional e as características inerentes da histologia cutânea.
Subject Chemistry; Other
Keyword Clareamento cutâneo, Inibição da tirosinase, Modelagem computacional
Notes Os dados não podem ser disponibilizados por questões de proteção intelectual. Estes se encontram submetidos para pedido de patente junto a INOVA. Para mais informações, entrar em contato com os responsáveis.
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