Análise dos mecanismos de ação de peptídeo sintetizado a partir de protótipo de veneno de aranha em linhagens de gliomas humanos

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Santos, Natália Barreto dos; Carneiro, Catarina Raposo Dias, 2026, "Análise dos mecanismos de ação de peptídeo sintetizado a partir de protótipo de veneno de aranha em linhagens de gliomas humanos", https://doi.org/10.25824/redu/LKHZCO, Repositório de Dados de Pesquisa da Unicamp , V1
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Description
Este conjunto de dados reúne informações geradas no âmbito de um projeto de pós-doutorado voltado à investigação dos mecanismos de ação do peptídeo LW-11 em modelos de glioma. Foram realizados ensaios experimentais in vitro e in vivo, incluindo análises de proteômica global por cromatografia líquida acoplada à espectrometria de massas (LC-MS/MS), avaliação de fosfoproteínas da via PI3K/AKT/mTOR por ensaio multiplex e análises histológicas em modelo murino de glioma. Os dados gerados incluem arquivos e planilhas provenientes das análises proteômicas, valores de intensidade de fluorescência obtidos no ensaio multiplex, imagens histológicas e planilhas de quantificação da área tumoral, além de registros experimentais associados. Esses dados foram utilizados para comparar grupos controle e tratados com o peptídeo LW-11 e para identificar proteínas, vias de sinalização e alterações morfológicas potencialmente relacionadas aos efeitos do tratamento. Os dados não podem ser disponibilizados por questões de proteção intelectual. Para mais informações, contatar os responsáveis. (2026)
Subject Medicine, Health and Life Sciences
Keyword Glioma, Migração celular, Phoneutria nigriventer, Terapia avançada
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