SDS-PAGE, fibrillogenesis, atomic force microscopy, DCFDA, Western blot and aggregometry raw and treated data from bovine and Rat-Tail collagen oxidized with hydrogen peroxide

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Mathias Netto, Felipe Caliani; Gaspar, Renato Simões, 2026, "SDS-PAGE, fibrillogenesis, atomic force microscopy, DCFDA, Western blot and aggregometry raw and treated data from bovine and Rat-Tail collagen oxidized with hydrogen peroxide", https://doi.org/10.25824/redu/U5AKHW, Repositório de Dados de Pesquisa da Unicamp , V1
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Description
Este conjunto reúne os registros experimentais brutos (imagens de géis, imagens de western blot e projetos de análise estatística/gráfica) produzidos durante o desenvolvimento da tese de doutorado em Farmacologia "The Effects of Hydrogen Peroxide-Induced Oxidation of Collagen on Platelet Aggregation" (Felipe Caliani Mathias Netto, sob orientação do Prof. Dr. Renato Simões Gaspar, Faculdade de Ciências Médicas, Unicamp). Os resultados incluem experimentos de SDS-PAGE, Western Blotting, agregação plaquetária por turbidimetria, agregação plaquetária em placa de 96 poços, ambos realizados na ausência e presença de antagonistas plaquetários, HPLC, microscopia de força atômica (AFM), fibrilogênese de colágeno, e DCFDA. O objetivo do trabalho foi avaliar como a oxidação do colágeno por peróxido de hidrogênio (H2O2), em diferentes razões molares colágeno:H2O2, altera (i) a estrutura do colágeno e (ii) a forma como ele ativa e sinaliza a agregação de plaquetas humanas. (2026-06-15)
Subject Medicine, Health and Life Sciences
Keyword Collagen, Platelets, Oxidation, Oxidative stress, Thrombosis
Related Publication MATHIAS NETTO, Felipe Caliani. The effects of hydrogen peroxide-induced oxidation of collagen on platelet aggregation. 2026. Tese (Doutorado em Farmacologia) - Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, 2026.
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Published Jul 2, 2026
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Conjunto de dados, contendo dados brutos (quando cabível) e tratados, quando necessário para a melhor compreensão e mais fácil localização de determinados resultados. Também contém dicionário de dados, com o nome e ao que cada arquivo se refere e também um readme com uma breve explicação sobre o dataset.
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